High-precision patch clamp electrophysiology to measure and interpret electrical and ionic function in single cells under controlled physiological conditions.
What we can do:
- Whole-cell and perforated patch clamp recordings
- Action potential clamp and voltage clamp protocols
- Functional characterization of ion channels, transporters, and membrane excitability
- Quantitative interpretation of electrophysiological data using mechanistic models
Cell types:
- Primary cardiomyocytes
- Other excitable cells (e.g. neurons, muscle cells)
- Non-excitable cells expressing ionic currents or transporters
- Engineered and transfected cell lines
Typical problems this enables:
- Functional validation of drug targets beyond expression data
- Mechanistic assessment of electrophysiological safety and efficacy