The Laboratory of Systems Biology at Tallinn University of Technology provides advanced experimental and computational services in cellular physiology, bioenergetics, electrophysiology, quantitative microscopy, and systems-level data analysis. Our expertise combines state-of-the-art measurements with mechanistic interpretation and mathematical modeling.
Our services are suitable for biotechnology and pharmaceutical companies, medical research projects, academic collaborations, and technology development.
Core Experimental and Analytical Services
Electrophysiology and Functional Cellular Analysis
Ion channel characterization and functional cellular phenotyping using advanced patch clamp electrophysiology. → Read more
Cellular Bioenergetics and Mitochondrial Function Analysis
High-resolution respirometry, mitochondrial function measurements, metabolic state analysis, and intracellular energy transfer studies. → Read more
Fluorescence Microscopy and Image Analysis
Confocal, TIRF, and super-resolution microscopy, live-cell imaging, diffusion analysis, and quantitative fluorescence data processing. → Read more
Mathematical Modeling and Quantitative Data Analysis
Mechanistic modeling of intracellular processes and quantitative analysis of experimental data. → Read more
Applied Testing Services
Drug Candidate Testing: Ion Channels and Membrane Electrophysiology
Assessment of drug candidate effects on ion channels, transporters, pumps, ionic currents, and membrane potential. In its core, it is using Electrophysiology and Functional Cellular Analysis to assess drug candidate effects.
Drug Candidate Testing: Cellular Metabolism and Bioenergetics
Evaluation of drug candidate effects on cellular metabolism, mitochondrial function, and energetic regulation. In its core, it is using Cellular Bioenergetics and Mitochondrial Function Analysis as well as elements of Fluorescence Microscopy and Image Analysis to assess drug candidate effects.
Drug Candidate Testing: Cardiomyocyte Contractility
Assessment of drug candidate effects on cardiomyocyte contraction and excitation–contraction coupling. For that, Microscopy and Image Analysis is combined with Electrophysiology and Functional Cellular Analysis.
Research Infrastructure and Expertise
The laboratory integrates expertise in:
- electrophysiology,
- calcium signaling,
- mitochondrial bioenergetics,
- quantitative fluorescence microscopy,
- computational modeling,
- and advanced data analysis.
Our team has extensive experience in interdisciplinary research combining biology, physics, mathematics, and computational approaches.