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Welcome to the Laboratory of Systems Biology
Diffusion of ATP and ADP is restricted in cardiomyocytes. Study made to investigate the distribution of the intracellular diffusion restrictions revealed tight functional coupling between some ATPases and pyruvate kinase. To find out more about the results, click here. Reference: Sepp et al, Biophys J 2010
Welcome to the site of the Laboratory of Systems Biology. The Laboratory of Systems Biology is a part of the Center for Nonlinear Studies in Institute Of Cybernetics, Tallinn University of Technology.
Aim
The main aim of the laboratory is to study regulation of intracellular processes and understand functional influences of intracellular interactions. For this, a mixture of experimental and theoretical approaches are used.Specific scientific interests, projects
- Intracellular compartmentation and diffusion restrictions, influence on bioenergetics
- How the fine structure of mitochondrion is influencing the dynamics of oxidative phosphorylation?
- Regulation of energy transfer in different types of cells
- Metabolic stability of heart muscle cells
- Interaction between mechanics and energetics of the heart
Support
The research in laboratory is financed byContact
Head: Marko Vendelin
Laboratory of Systems Biology
Institute of Cybernetics at Tallinn University of Technology
Akadeemia 21
12618 Tallinn
Estonia
Fax: +372 620 4151
Phone: +372 620 4169
http://sysbio.ioc.ee