Welcome to the Laboratory of Systems Biology
Red and green vehicles represent molecules with different diffusion coefficients: small molecules are represented by a fast red car and big molecules by a large green truck. In solution surrounding the cell (on the highway), diffusion is unhindered and the diffusion coefficient of smaller molecules (fluorescent ATP in this case) is almost 4 times higher than of a larger molecule (fluorescent Dextran 10K). In the cardiomyocyte, diffusion restrictions imposed by intracellular structures lead to considerably smaller difference between estimated diffusion coefficients (1.7 times). See Illaste et al, Biophys J 2012 for measurement results and computational model explaining this counter-intuitive result. (Author of image: Erik Illaste)
Welcome to the site of the Laboratory of Systems Biology. The Laboratory of Systems Biology is a part of the Center for Nonlinear Studies in Institute Of Cybernetics, Tallinn University of Technology.
AimThe main aim of the laboratory is to study regulation of intracellular processes and understand functional influences of intracellular interactions. For this, a mixture of experimental and theoretical approaches are used.
Specific scientific interests, projects
- Intracellular compartmentation and diffusion restrictions, influence on bioenergetics
- How the fine structure of mitochondrion is influencing the dynamics of oxidative phosphorylation?
- Regulation of energy transfer in different types of cells
- Metabolic stability of heart muscle cells
- Interaction between mechanics and energetics of the heart
SupportThe research in laboratory is financed by
Head: Marko Vendelin
Laboratory of Systems Biology
Institute of Cybernetics
Tallinn University of Technology
Fax: +372 620 4151
Phone: +372 620 4169