I am the head of Laboratory of Systems Biology and Professor in Biophysics at the Department of Cybernetics. I have defended by PhD in 2001 (Institute of Cybernetics at Tallinn University of Technology). After continuing my research in the Institute of Cybernetics (2002), I was a post-doctoral fellow at Université J. Fourier (2003-2004, Laboratory of Fundamental and Applied Bioenergetics, INSERM E0221) and Université Paris-Sud (2005, Faculté de Pharmacie, INSERM U446). After the post-doctorall studies, I returned to the Institute of Cybernetics and, with the help of Wellcome Trust International Senior Research Fellowship, started Laboratory of Systems Biology (2007).
Research Interests
My general research interests are linked with the physiology of the heart. I am interested in regulation of bioenergetics, its link to mechanics and electrophysiology. As a part of studies of regulation of intracellular processes in the heart, I am studying molecular movements and how intracellular communication is influenced by local environment as well as different diffusion obstacles in the heart muscle cells. For specific aims and interests, see the general homepage of Laboratory of Systems Biology.
Contact
e-mail: markov@sysbio.ioc.ee
Address:
Laboratory of Systems BiologyDepartment of Cybernetics
School of Science
Tallinn University of Technology
Akadeemia 15,
12618 Tallinn
ESTONIA
phone: (+372) 620 4169
Last Publications
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Branovets, J., Laasmaa, M., Stolova, J., Shen, X., Rätsepso, T., Bernasconi, R., Soodla, K., Balodis, M. J., Grahv, C., Hendrikson, E., Louch, W. E., Birkedal, R., & Vendelin, M. (2025). Lifelong creatine deficiency leads to augmented sarcoplasmic reticulum calcium release but not heart failure. American Journal of Physiology-Heart and Circulatory Physiology, 329(2), H471–H489. https://doi.org/10.1152/ajpheart.00106.2025
Karimi, H., Laasmaa, M., Pihlak, M., & Vendelin, M. (2025). Statistical analysis of fluorescence intensity transients with Bayesian methods. Science Advances, 11(16), eads4609. https://doi.org/10.1126/sciadv.ads4609
Bernasconi, R., Soodla, K., Sirp, A., Zovo, K., Kuhtinskaja, M., Lukk, T., Vendelin, M., & Birkedal, R. (2025). Higher AMPK activation in mouse oxidative compared with glycolytic muscle does not correlate with LKB1 or CaMKKβ expression. American Journal of Physiology-Endocrinology and Metabolism, 328(1), E21–E33. https://doi.org/10.1152/ajpendo.00261.2024
Suut-Tuule, E., Jarg, T., Tikker, P., Lootus, K.-M., Martõnova, J., Reitalu, R., Ustrnul, L., Ward, J. S., Rjabovs, V., Shubin, K., Nallaparaju, J. V., Vendelin, M., Preis, S., Öeren, M., Rissanen, K., Kananovich, D., & Aav, R. (2024). Mechanochemically driven covalent self-assembly of a chiral mono-biotinylated hemicucurbit[8]uril. Cell Reports Physical Science, 5(9), 102161. https://doi.org/10.1016/j.xcrp.2024.102161
Jaska, L., Birkedal, R., Laasmaa, M., & Vendelin, M. (2024). Simple Analysis of Gel Images With IOCBIO Gel Software. Bio-Protocol, 14(16), e5053. https://doi.org/10.21769/BioProtoc.5053
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