Martin Laasmaa – Laboratory of Systems Biology

Currently, I am working as an assistant professor at the Laboratory of Systems Biology. My main research interests include calcium handling during excitation-contraction coupling and molecule movements in cardiomyocytes.

Contact

Email: martin@sysbio.ioc.ee
Address:
Laboratory of Systems Biology
Department of Cybernetics
School of Science
Tallinn University of Technology
Akadeemia tee 15
12618 Tallinn
Estonia
Phone: (+372) 620 4406

Other Resources

Estonian Science Portal
ResearchGate

Publications

4906808 BJ28HM24 laasmaa 1 apa 50 date desc 64 https://sysbio.ioc.ee/wp-content/plugins/zotpress/

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0formula%20to%20estimate%20this%20regularization%20parameter%20automatically%20from%20the%20images%20as%20the%20algorithm%20progresses.%20To%20assess%20the%20effectiveness%20of%20this%20algorithm%2C%20synthetic%20images%20were%20composed%20on%20the%20basis%20of%20confocal%20images%20of%20rat%20cardiomyocytes.%20From%20the%20analysis%20of%20deconvolved%20results%2C%20we%20have%20determined%20under%20which%20conditions%20our%20estimation%20of%20total%20variation%20regularization%20parameter%20gives%20good%20results.%20The%20estimated%20total%20variation%20regularization%20parameter%20can%20be%20monitored%20during%20deconvolution%20process%20and%20used%20as%20a%20stopping%20criterion.%20An%20inverse%20relation%20between%20the%20optimal%20regularization%20parameter%20and%20the%20peak%20signal-to-noise%20ratio%20of%20an%20image%20is%20shown.%20Finally%2C%20we%20demonstrate%20the%20use%20of%20the%20developed%20software%20by%20deconvolving%20images%20of%20rat%20cardiomyocytes%20with%20stained%20mitochondria%20and%20sarcolemma%20obtained%20by%20confocal%20and%20widefield%20microscopes.%22%2C%22date%22%3A%22Aug%202011%22%2C%22section%22%3A%22%22%2C%22partNumber%22%3A%22%22%2C%22partTitle%22%3A%22%22%2C%22DOI%22%3A%2210.1111%5C%2Fj.1365-2818.2011.03486.x%22%2C%22citationKey%22%3A%22laasmaaApplicationRegularizedRichardsonLucy2011b%22%2C%22url%22%3A%22http%3A%5C%2F%5C%2Fwww.ncbi.nlm.nih.gov%5C%2Fpubmed%5C%2F21323670%22%2C%22PMID%22%3A%2221323670%22%2C%22PMCID%22%3A%22%22%2C%22ISSN%22%3A%221365-2818%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%22BJ28HM24%22%2C%22ZX2RBW5Y%22%5D%2C%22dateModified%22%3A%222026-02-17T09%3A04%3A07Z%22%7D%7D%5D%7D

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Branovets, J., Laasmaa, M., Stolova, J., Shen, X., Rätsepso, T., Bernasconi, R., Soodla, K., Balodis, M. J., Grahv, C., Hendrikson, E., Louch, W. E., Birkedal, R., & Vendelin, M. (2025). Lifelong creatine deficiency leads to augmented sarcoplasmic reticulum calcium release but not heart failure. American Journal of Physiology-Heart and Circulatory Physiology, 329(2), H471–H489. https://doi.org/10.1152/ajpheart.00106.2025

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Kütt, J., Margus, G., Kask, L., Rätsepso, T., Soodla, K., Bernasconi, R., Birkedal, R., Järv, P., Laasmaa, M., & Vendelin, M. (2023). Simple analysis of gel images with IOCBIO Gel. BMC Biology, 21(1), 225. https://doi.org/10.1186/s12915-023-01734-8

Li, J., Sundnes, J., Hou, Y., Laasmaa, M., Ruud, M., Unger, A., Kolstad, T. R., Frisk, M., Norseng, P. A., Yang, L., Setterberg, I. E., Alves, E. S., Kalakoutis, M., Sejersted, O. M., Lanner, J. T., Linke, W. A., Lunde, I. G., de Tombe, P. P., & Louch, W. E. (2023). Stretch Harmonizes Sarcomere Strain Across the Cardiomyocyte. Circulation Research, 133(3), 255–270. https://doi.org/10.1161/CIRCRESAHA.123.322588

Hou, Y., Laasmaa, M., Li, J., Shen, X., Manfra, O., Nordén, E. S., Le, C., Zhang, L., Sjaastad, I., Jones, P. P., Soeller, C., & Louch, W. E. (2023). Live-cell photoactivated localization microscopy correlates nanoscale ryanodine receptor configuration to calcium sparks in cardiomyocytes. Nature Cardiovascular Research, 2(3), 251–267. https://doi.org/10.1038/s44161-022-00199-2

Laasmaa, M., Branovets, J., Stolova, J., Shen, X., Rätsepso, T., Balodis, M. J., Grahv, C., Hendrikson, E., Louch, W. E., Birkedal, R., & Vendelin, M. (2023). Cardiomyocytes from female compared to male mice have larger ryanodine receptor clusters and higher calcium spark frequency. The Journal of Physiology, 601(18), 4033–4052. https://doi.org/10.1113/JP284515

Birkedal, R., Laasmaa, M., Branovets, J., & Vendelin, M. (2022). Ontogeny of cardiomyocytes: ultrastructure optimization to meet the demand for tight communication in excitation–contraction coupling and energy transfer. Philosophical Transactions of the Royal Society B: Biological Sciences, 377(1864), 20210321. https://doi.org/10.1098/rstb.2021.0321

Shen, X., van den Brink, J., Bergan-Dahl, A., Kolstad, T. R., Norden, E. S., Hou, Y., Laasmaa, M., Aguilar-Sanchez, Y., Quick, A. P., Espe, E. K., Sjaastad, I., Wehrens, X. H., Edwards, A. G., Soeller, C., & Louch, W. E. (2022). Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure. eLife, 11, e77725. https://doi.org/10.7554/eLife.77725

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Branovets, J., Karro, N., Barsunova, K., Laasmaa, M., Lygate, C. A., Vendelin, M., & Birkedal, R. (2021). Cardiac expression and location of hexokinase changes in a mouse model of pure creatine deficiency. American Journal of Physiology-Heart and Circulatory Physiology, 320(2), H613–H629. https://doi.org/10.1152/ajpheart.00188.2020

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Rubinstein, J., Woo, J. G., Garcia, A. M., Alsaied, T., Li, J., Lunde, P. K., Moore, R. A., Laasmaa, M., Sammons, A., Mays, W. A., Miyamoto, S. D., Louch, W. E., & Veldtman, G. R. (2020). Probenecid Improves Cardiac Function in Subjects with a Fontan Circulation and Augments Cardiomyocyte Calcium Homeostasis. Pediatric Cardiology, 41(8), 1675–1688. https://doi.org/10.1007/s00246-020-02427-7

Tazmini, K., Frisk, M., Lewalle, A., Laasmaa, M., Morotti, S., Lipsett, D. B., Manfra, O., Skogestad, J., Aronsen, J. M., Sejersted, O. M., Sjaastad, I., Edwards, A. G., Grandi, E., Niederer, S. A., Øie, E., & Louch, W. E. (2020). Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes. Circulation Research, 126(7), 889–906. https://doi.org/10.1161/CIRCRESAHA.119.315641

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Laasmaa, M., Lu, P., Veletić, M., Louch, W. E., Bergsland, J., Balasingham, I., & Vendelin, M. (2019). Energy-efficiency of Cardiomyocyte Stimulation with Rectangular Pulses. Scientific Reports, 9(1), 1–9. https://doi.org/10.1038/s41598-019-49791-w

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Laasmaa, M., Karro, N., Birkedal, R., & Vendelin, M. (2019). IOCBIO Sparks detection and analysis software. PeerJ, 7, e6652. https://doi.org/10.7717/peerj.6652

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Laasmaa, M., Birkedal, R., & Vendelin, M. (2016). Revealing calcium fluxes by analyzing inhibition dynamics in action potential clamp. Journal of Molecular and Cellular Cardiology, 100, 93–108. https://doi.org/10.1016/j.yjmcc.2016.08.015

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