News

Cross-Bridge Group Ensembles Describing Cooperativity in Thermodynamically Consistent Way

Mari Kalda, Pearu Peterson, Marko Vendelin

PLoS One, 2015; 10(9): e0137438.

• PMID: 26361396
• DOI: 10.1371/journal.pone.0137438

Significance

Muscle contraction depends on molecular motors called...

The location of energetic compartments affects energetic communication in cardiomyocytes

Rikke Birkedal, Martin Laasmaa, Marko Vendelin

Front Physiol, 2014; 5: 376.

• PMID: 25324784
• DOI: 10.3389/fphys.2014.00376

Significance

Heart cells must continuously match energy production to t...

Tight coupling of Na+/K+-ATPase with glycolysis demonstrated in permeabilized rat cardiomyocytes

Mervi Sepp, Niina Sokolova, Svetlana Jugai, Merle Mandel, Pearu Peterson, Marko Vendelin

PLoS One, 2014; 9(6): e99413.

• PMID: 24932585
• DOI: 10.1371/journal.pone.0099413

Significance

Hea...

ADP protects cardiac mitochondria under severe oxidative stress

Niina Sokolova, Shi Pan, Sarah Provazza, Gisela Beutner, Marko Vendelin, Rikke Birkedal, Shey-Shing Sheu

PLoS One, 2013; 8(12): e83214.

• PMID: 24349464
• DOI: 10.1371/journal.pone.0083214

Significance

Mitochondria supply...

Unchanged mitochondrial organization and compartmentation of high-energy phosphates in creatine-deficient GAMT-/- mouse hearts

Jelena Branovets, Mervi Sepp, Svetlana Kotlyarova, Natalja Jepihhina, Niina Sokolova, Dunja Aksentijevic, Craig A Lygate, Stefan Neubauer, Marko Vendelin, Rikke Birkedal

Real-time determination of sarcomere length of a single cardiomyocyte during contraction

Pearu Peterson, Mari Kalda, Marko Vendelin

Am J Physiol Cell Physiol, 2013 Mar; 304(6): C519-31.

• PMID: 23255581
• DOI: 10.1152/ajpcell.00032.2012

Significance

Measuring the spacing of the force-...

Sensitivity analysis of flux determination in heart by H₂ ¹⁸O -provided labeling using a dynamic Isotopologue model of energy transfer pathways

David W Schryer, Pearu Peterson, Ardo Illaste, Marko Vendelin

PLoS Comput Biol, 2012; 8(12): e1002795.

• PMID: 23236266
• DOI: 10.1371/journal.pcbi...

Molecular dynamics simulations of creatine kinase and adenine nucleotide translocase in mitochondrial membrane patch

Jaanus Karo, Pearu Peterson, Marko Vendelin

J Biol Chem, 2012 Mar 02; 287(10): 7467-76.

• PMID: 22241474
• DOI: 10.1074/jbc.M111.332320

Significance

Mitochondria make t...

Analysis of molecular movement reveals latticelike obstructions to diffusion in heart muscle cells

Ardo Illaste, Martin Laasmaa, Pearu Peterson, Marko Vendelin

Biophys J, 2012 Feb 22; 102(4): 739-48.

• PMID: 22385844
• DOI: 10.1016/j.bpj.2012.01.012

Significance

Molecules must move th...

Permeabilized rat cardiomyocyte response demonstrates intracellular origin of diffusion obstacles

Natalja Jepihhina, Nathalie Beraud, Mervi Sepp, Rikke Birkedal, Marko Vendelin

Biophys J, 2011 Nov 02; 101(9): 2112-21.

• PMID: 22067148
• DOI: 10.1016/j.bpj.2011.09.025

Significance

Hear...