News

Lifelong creatine deficiency leads to augmented sarcoplasmic reticulum calcium release but not heart failure

Jelena Branovets, Martin Laasmaa, Jekaterina Stolova, Xin Shen, Triinu Rätsepso, Romain Bernasconi, Kärol Soodla, Mihkel Jaan Balodis, Cärolin Grahv, Eliise Hendrikson, William Edward Louch...

Cardiomyocytes from female compared to male mice have larger ryanodine receptor clusters and higher calcium spark frequency

Martin Laasmaa, Jelena Branovets, Jekaterina Stolova, Xin Shen, Triinu Rätsepso, Mihkel Jaan Balodis, Cärolin Grahv, Eliise Hendrikson, William Edward Louch, Rikke Birkedal,...

Ontogeny of cardiomyocytes: ultrastructure optimization to meet the demand for tight communication in excitation-contraction coupling and energy transfer

Rikke Birkedal, Martin Laasmaa, Jelena Branovets, Marko Vendelin

Philos Trans R Soc Lond B Biol Sci, 2022 Nov 21; 377(1864): 20210321.

• PM...

Congratulations to Jelena Branovets, who defended her doctoral thesis, Energetics and Calcium Handling in Hearts from Creatine-Deficient Mice, at TalTech on 29 September 2022.

The creatine kinase system helps the heart match energy production to the energy needed for every contraction. Jelena's...

Altered calcium handling in cardiomyocytes from arginine-glycine amidinotransferase-knockout mice is rescued by creatine

Martin Laasmaa, Jelena Branovets, Karina Barsunova, Niina Karro, Craig A Lygate, Rikke Birkedal, Marko Vendelin

Am J Physiol Heart Circ Physiol, 2021 Feb 01; 320(2): H805-H82...

Cardiac muscle regulatory units are predicted to interact stronger than neighboring cross-bridges

Mari Kalda, Marko Vendelin

Sci Rep, 2020 Mar 26; 10(1): 5530.

• PMID: 32218497
• DOI: 10.1038/s41598-020-62452-7

Significance

Heart muscle cells respond steeply to small increases in calc...

Metabolic compartmentation in rainbow trout cardiomyocytes: coupling of hexokinase but not creatine kinase to mitochondrial respiration

Niina Karro, Mervi Sepp, Svetlana Jugai, Martin Laasmaa, Marko Vendelin, Rikke Birkedal

J Comp Physiol B, 2017 Jan; 187(1): 103-116.

• PMID: 27522222
• DOI:...

Cross-Bridge Group Ensembles Describing Cooperativity in Thermodynamically Consistent Way

Mari Kalda, Pearu Peterson, Marko Vendelin

PLoS One, 2015; 10(9): e0137438.

• PMID: 26361396
• DOI: 10.1371/journal.pone.0137438

Significance

Muscle contraction depends on molecular motors called...

ADP protects cardiac mitochondria under severe oxidative stress

Niina Sokolova, Shi Pan, Sarah Provazza, Gisela Beutner, Marko Vendelin, Rikke Birkedal, Shey-Shing Sheu

PLoS One, 2013; 8(12): e83214.

• PMID: 24349464
• DOI: 10.1371/journal.pone.0083214

Significance

Mitochondria supply...

Sensitivity analysis of flux determination in heart by H₂ ¹⁸O -provided labeling using a dynamic Isotopologue model of energy transfer pathways

David W Schryer, Pearu Peterson, Ardo Illaste, Marko Vendelin

PLoS Comput Biol, 2012; 8(12): e1002795.

• PMID: 23236266
• DOI: 10.1371/journal.pcbi...