News

Altered calcium handling in cardiomyocytes from arginine-glycine amidinotransferase-knockout mice is rescued by creatine

Martin Laasmaa, Jelena Branovets, Karina Barsunova, Niina Karro, Craig A Lygate, Rikke Birkedal, Marko Vendelin

Am J Physiol Heart Circ Physiol, 2021 Feb 01; 320(2): H805-H82...

IOCBIO Kinetics: An open-source software solution for analysis of data traces

Marko Vendelin, Martin Laasmaa, Mari Kalda, Jelena Branovets, Niina Karro, Karina Barsunova, Rikke Birkedal

PLoS Comput Biol, 2020 Dec; 16(12): e1008475.

• PMID: 33351800
• DOI: 10.1371/journal.pcbi.1008475

Si

Marker enzyme activities in hindleg from creatine-deficient AGAT and GAMT KO mice - differences between models, muscles, and sexes

Karina Barsunova, Marko Vendelin, Rikke Birkedal

Sci Rep, 2020 May 14; 10(1): 7956.

• PMID: 32409787
• DOI: 10.1038/s41598-020-64740-8

Significance

Creati...

Cardiac muscle regulatory units are predicted to interact stronger than neighboring cross-bridges

Mari Kalda, Marko Vendelin

Sci Rep, 2020 Mar 26; 10(1): 5530.

• PMID: 32218497
• DOI: 10.1038/s41598-020-62452-7

Significance

Heart muscle cells respond steeply to small increases in calc...

Energy-efficiency of Cardiomyocyte Stimulation with Rectangular Pulses

Martin Laasmaa, Pengfei Lu, Mladen Veletić, William E Louch, Jacob Bergsland, Ilangko Balasingham, Marko Vendelin

Sci Rep, 2019 Sep 16; 9(1): 13307.

• PMID: 31527628
• DOI: 10.1038/s41598-019-49791-w

Significance

P...

Respiration of permeabilized cardiomyocytes from mice: no sex differences, but substrate-dependent changes in the apparent ADP-affinity

Niina Karro, Martin Laasmaa, Marko Vendelin, Rikke Birkedal

Sci Rep, 2019 Aug 29; 9(1): 12592.

• PMID: 31467353
• DOI: 10.1038/s41598-019-48964-x

Signi

IOCBIO Sparks detection and analysis software

Martin Laasmaa, Niina Karro, Rikke Birkedal, Marko Vendelin

PeerJ, 2019; 7: e6652.

• PMID: 30956900
• DOI: 10.7717/peerj.6652

Significance

Calcium sparks are brief, localized releases of calcium that help control heart-cell contraction and...

Revealing calcium fluxes by analyzing inhibition dynamics in action potential clamp

Martin Laasmaa, Rikke Birkedal, Marko Vendelin

J Mol Cell Cardiol, 2016 Nov; 100: 93-108.

• PMID: 27702573
• DOI: 10.1016/j.yjmcc.2016.08.015

Significance

Calcium drives each heartbeat, but several tig...

Metabolic compartmentation in rainbow trout cardiomyocytes: coupling of hexokinase but not creatine kinase to mitochondrial respiration

Niina Karro, Mervi Sepp, Svetlana Jugai, Martin Laasmaa, Marko Vendelin, Rikke Birkedal

J Comp Physiol B, 2017 Jan; 187(1): 103-116.

• PMID: 27522222
• DOI:...

Restricted ADP movement in cardiomyocytes: Cytosolic diffusion obstacles are complemented with a small number of open mitochondrial voltage-dependent anion channels

Päivo Simson, Natalja Jepihhina, Martin Laasmaa, Pearu Peterson, Rikke Birkedal, Marko Vendelin

J Mol Cell Cardiol, 2016 Aug; 97:...