Advanced quantitative fluorescence microscopy & signal analysis

Extraction of quantitative parameters from live- and fixed-cell fluorescence data. 

What we can do: 

• Confocal, TIRF, and epifluorescence microscopy 

• Superresolution fluorescence microscopy (dSTORM, DNA-PAINT) 

• Raster image correlation spectroscopy and diffusion analysis 

• Fluorescence Correlation Spectroscopy 

• Three-dimensional analysis of subcellular organization in live cells 

• Image deconvolution and resolution enhancement 

• Open-source, reproducible analysis pipelines 

Typical problems this enables: 

• Detection of early structural dysfunction 

• Understanding how cellular architecture constrains function 

• Identification of structural biomarkers linked to disease progression