Advanced electrophysiology & functional cellular phenotyping

High-precision patch clamp electrophysiology to measure and interpret electrical and ionic function in single cells under controlled physiological conditions. 

What we can do: 

• Whole-cell and perforated patch clamp recordings 

• Action potential clamp and voltage clamp protocols 

• Functional characterization of ion channels, transporters, and membrane excitability 

• Quantitative interpretation of electrophysiological data using mechanistic models 

Cell types: 

• Primary cardiomyocytes 

• Other excitable cells (e.g. neurons, muscle cells) 

• Non-excitable cells expressing ionic currents or transporters 

• Engineered and transfected cell lines 

Typical problems this enables: 

• Functional validation of drug targets beyond expression data 

• Mechanistic assessment of electrophysiological safety and efficacy